Anti Aging After 50

Anti Aging After 50

Understanding the Signs and Symptoms of Cognitive Decline

Anti Aging After 50You will at times hear older people and senior citizens say that their memory is “failing”. It’s amazing how some of the elderly can recall in every little detail events that happened tens of years earlier, but they struggle to remember an event that took place only a day or two earlier. Cognitive decline is the name given to this disorder.

In the past this would have been simply put down as a natural symptom of getting old, just part of the aging process.

The first signs that someone might be suffering with the disorder can be marked by their inability to deal with simple input tasks, not able to fully process basic information and poor judgement. Although the problem can on first inspection seem to be related to aging, it is becoming clearer that the real cause of cognitive decline can not all be lumped at the door of old age or cured by anti aging brain supplements.

The medical profession refer to cognitive decline as mild cognitive impairment or M.C.I for short and the unfortunate thing is that the sufferer will not always be aware they have a problem until someone close to them points it out. Sufferers of M.C.I will often go on to sufferer with Alzheimer’s Disease. Though the progression of M.C.I can be slow, those close to the sufferer, given adequate knowledge of the signs and symptoms, should be able to spot they are indeed experiencing some measure of cognitive decline.

It is all about educating ourselves enough to spot the following early symptom and signs of M.C.I.

  • Do they tend to forget everyday important personal information that in the past they knew, say their Birthday or Wedding Anniversary.
  • Inability to remember familiar words and friends or family names
  • Lack of visual perception
  • Not remembering if they have eaten their last meal or even eaten that day at all
  • Heightened ability to remember in detail things that occurred 30, 40 or more years previous
  • Decreased eye-hand coordination judgement, time/distance relationships and fine motor skills
  • Forgetting where everyday household items are kept
  • Having just read or watched something have they not digesting it enough to recall it only moments later
  • Continually misplacing or losing keys, wallet and phone
  • Not able to organize or plan simple tasks

2 or more of the signs above present in a loved one? sit them down and have a discussion with them about what you have noticed. Don’t be surprised if their initial reaction is one of denial, this is a common response when a persons weakened mental capability is mentioned and in itself can also be classed as a sign of them suffering from M.C.I.. Make an early appointment with a doctor or health professional to get your initial thoughts checked out.

Anti Aging After 50

Causes of Dementia and Cognitive Decline


So what measures can you include in an anti aging regime to combat the effects that M.C.I or other types of cognitive decline have in old age. One easy trick is to maintain cardiovascular health by exercising regularly. There’s no need to over do this, steady exercise or a brisk walk is enough to get the heart rate up and blood pumping to the areas where it’s needed.

Anti Aging After 50 Brain GamesTake an active part in social activities that include some level of mental stimulation. Play or take up chess as things that challenge the mind are a proven way of preventing and treating cognitive decline in older people and chess is just one of many effective anti aging brain exercises.

So to sum up, by adding regularly exercise, getting plenty of sleep, keeping the mind challenged by playing anti aging mind games and staying socially engaged to a balanced anti aging after 50 regime will maintain the minds health long into peoples senior years.


Anti Aging Plan Not Working?

Ageing fast? It might be your ‘biological age’

Anti Aging Happy BirthdayFor most of us ageing is simply denoted by how many candles you get on your cake each year – however it turns out we might have a ‘biological age’ as well.

And this ‘biological age’ may well determine why some people seem to be ageing faster than others.

A new study suggests that people can be ageing three times faster than their age suggests.

Scientists at Duke University in North Carolina looked into people genes and were able to determine how fast they were ageing.

Anti Ageing Bio AgeThey found that in their group of 38-year-old participants, people had biological ages ranging from 28 to 61.

The study started when the participants were 26, at which point they had their genes inspected, and then again at the age of 32, and once more at the age of 38.

Some were found to have bodies aging three times fast than their chronological ageing, while others seemingly didn’t biologically age at all.

Dr Dan Belsky, Duke University Centre for Ageing, said the study could help prevent age related diseases.

‘As we get older, our risk grows for all kinds of different diseases. To prevent multiple diseases simultaneously, ageing itself has to be the target,’ he added.


Universal Mechanism for Activating Anti Aging Pathway

New Study Validates Longevity Pathway: Findings Identify Universal Mechanism for Activating Anti Aging Pathway

Thanks to where this article was first published.
It looks like we are a step nearer to unlocking the science behind a new generation of anti aging treatments, medicines and tablets.  Read on to get the full picture…

A new study demonstrates what researchers consider conclusive evidence that the red wine compound resveratrol directly activates a protein that promotes health and longevity in animal models. What’s more, the researchers have uncovered the molecular mechanism for this interaction, and show that a class of more potent (anti aging) drugs currently in clinical trials act in a similar fashion. Pharmaceutical compounds similar to resveratrol may potentially be used as anti aging treament and prevent diseases related to aging in people, the authors contend.

These findings are published in the March 8 issue of Science.

For the last decade, the science of aging has increasingly focused on sirtuins, a group of genes that are believed to protect many organisms, including mammals, against diseases of aging. Mounting evidence has demonstrated that resveratrol, a compound found in the skin of grapes as well as in peanuts and berries, increases the activity of a specific sirtuin,SIRT1, that protects the body from diseases by revving up the mitochondria, a kind of cellular battery that slowly runs down as we age. By recharging the batteries, SIRT1 can have profound effects on health.

nti Aging Resveratrol GraphMice on resveratrol have twice the endurance and are relatively immune from effects of obesity and aging. In experiments with yeast, nematodes, bees, flies and mice, lifespan has been extended.

“In the history of pharmaceuticals, there has never been a drug that binds to a protein to make it run faster in the way that resveratrol activates SIRT1,” said David Sinclair, Harvard Medical School professor of genetics and senior author on the paper. “Almost all anti aging drugs either slow or block them.”

In 2006, Sinclair’s group published a study showing that resveratrol could extend the lifespan of mice, and the company Sirtris Pharmaceuticals, which was started by HMS researchers, was founded to make drugs more potent than resveratrol. (Sinclair is a co-founder of Sirtris, a GlaxoSmithKline company, and remains a scientific advisor. Sirtris currently has a number of sirtuin-activating compounds in clinical trials.)

But while numerous studies, from Sinclair’s lab and elsewhere, underscored a direct causal link between resveratrol and SIRT1, some scientists claimed the studies were flawed.

The contention lay in the way SIRT1 was studied in vitro, using a specific chemical group attached to the targets of SIRT1 that fluoresces more brightly as SIRT1 activity increases. This chemical group, however, is synthetic and does not exist in cells or in nature, and without it the experiments did not work. As a response to this, a paper published in 2010 surmised that resveratrol’s activation of SIRT1 was an experimental artifact, one that existed in the lab, but not in an actual animal. SIRT1 activity in mice was, the paper claimed, at best an indirect result of resveratrol, and perhaps even a sheer coincidence.

As a result, a debate erupted over the particular pathway that resveratrol and similar compounds affected. Does resveratrol directly activate SIRT1 or is the effect indirect? “We had six years of work telling us that this was most definitely not an artifact,” said Sinclair. “Still, we needed to figure out precisely how resveratrol works. The answer was extremely elegant.”

Sinclair and Basil Hubbard, then a doctoral student in the lab, teamed up with a group of researchers from both the National Institutes of Health and Sirtris Pharmaceuticals to address this question.

Anti Aging Tablets MedicineFirst, the team addressed the problem of the fluorescent chemical group. Why was it required for resveratrol to rev up SIRT1 in the test tube? Instead of dismissing the result as an artifact, the researchers surmised that the chemical might be mimicking molecules found naturally in the cell. These turned out to be a specific class of amino acid, the building blocks of proteins. In nature, there are three amino acids that resemble the fluorescent chemical group, one of which is tryptophan, a molecule abundant in turkey and notable for inducing drowsiness. When researchers repeated the experiment, swapping the fluorescing chemical group on the substrate with a tryptophan residue, resveratrol and similar molecules were once again able to activate SIRT1.

“We discovered a signature for activation that is in fact found in the cell and doesn’t require these other synthetic groups,” said Hubbard, first author of the study. “This was a critical result, which allowed us to bridge the gap between our biochemical and physiological findings.

“Next, we needed to identify precisely how resveratrol presses on SIRT1′s accelerator,” said Sinclair. The team tested approximately 2,000 mutants of the SIRT1 gene, eventually identifying one mutant that completely blocked resveratrol’s effect. The particular mutation resulted in the substitution of a single amino acid residue, out of the 747 that make up SIRT1. The researchers also tested hundreds of other molecules from the Sirtris library, many of which are far more powerful than resveratrol, against this mutant SIRT1. All failed to activate it.

The authors propose a model for how resveratrol works: When the molecule binds, a hinge flips, and SIRT1 becomes hyperactive.

Although these experiments occurred in a test tube, once the researchers identified the precise location of the accelerator pedal on SIRT1 — and how to break it — they could test their ideas in a cell. They replaced the normal SIRT1 gene in muscle and skin cells with the accelerator-dead mutant. Now they could test precisely whether resveratrol and the drugs in development work by tweaking SIRT1 (in which case they would not work) or one of the thousands of other proteins in a cell (in which they would work). While resveratrol and the drugs tested revved up mitochondria in normal cells (an effect caused activating by SIRT1), the mutant cells were completely immune.

“This was the killer experiment,” said Sinclair. “There is no rational alternative explanation other than resveratrol directly activates SIRT1 in cells. Now that we know the exact location on SIRT1 where and how resveratrol works, we can engineer even better molecules that more precisely and effectively trigger the effects of resveratrol.”

The researchers plan on continuing academic-industry collaborations with the goal of bringing to fruition anti aging drugs that treat diseases associated with aging.

This research was funded by the Glenn Foundation for Medical Research, the Ellison Medical Foundation, the Juvenile Diabetes Research Foundation, the United Mitochondrial Disease Foundation, NIH and NIAID grants (RO1AG028730, PO1AG027211; RO1 AG019719), an NSERC fellowship, the Portuguese Science and Technology Foundation, the Intramural Research Program, and NIH/NHLBI.

Sinclair is a consultant and inventor on patents licensed to Sirtris, a GSK company.

Is Resveratrol An Anti Aging Miracle