Anti Aging Skin Care Ingredients | Glossary Of Terms

Top Rated Anti Aging Skin Care Ingredients

Glossary of Terms of Ingredients in Anti Aging Skin Care Products

A quick look at some of the best anti aging skin care ingredients so you can better understand how they work and where they might fit into your anti aging beauty routine.

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Anti Aging Science1-Methylhydantoin-2-imide (Tego Cosmo). Blocks the enzyme that produces melanin to reduce discoloration.

Ascorbic Acid Polypeptide. A reaction product of ascorbic acid and hydrolyzed protein.

Alpha Hydroxy Acids.  Anti aging skin care ingredients that aid exfoliation by weakening the links between cells in the outer layer of dead skin, allowing the normal shedding process to occur at a more optimum rate.  By helping new cells surface, they improve skin texture, unclog pores and facilitate absorption of moisturizers.  It may also help play a role in building skin-firming collagen and elastin, especially when incorporated into a two-step chemical peel.  AHAs include lactic (from dairy products), glycolic (from sugar), malic (from apples) and citric (from citrus fruits).  Dr. Gross has found that skincare products with several different kinds of acids (AHA and BHA) are the most effective and least irritating, because when many acids are combined, each can be used in a lower (i.e. milder) concentration.

Anti Aging ScienceAminobutyric Acid (GABA).  Reduces fine lines and wrinkles immediately.

Antioxidants.  Serve as the antidote to free radicals by neutralizing their detrimental effects on collagen in the skin. For example, visualize free radicals as tiny darts poking holes in collagen. The bad news: As we age, our bodies no longer produce sufficient antioxidants to fight free radicals. The good news: Just as there are different species of free radicals, modern science has identified different kinds of antioxidants to combat them.  Dr. Gross recommends using products containing as many different kinds of antioxidants as possible.

Anti Aging ScienceAllantoin.  A substance known for its healing, soothing and anti-irritating properties.  Softens skin and stimulates the formation of healthy tissue.  Helps eliminate chapping and cracking, leaving skin silky, smooth and healthy-looking.  Found in herbs such as comfrey, wheat and sugar beets.

Natural Anti AgingAloe Barbadensis Leaf Extract (Aloe). Moisturizes, soothes, anti-inflammatory, wound-healing.

Natural Anti AgingArbutin. Inhibits melanin production in the skin.

NatureArnica Extract. An ingredient that improves the appearance of dry or damaged skin by reducing flaking and restoring suppleness.

Anti Aging ScienceAvobenzone (Parsol 1789). A chemical sunscreen that offers broad range protection against UVA rays.

Ayurvedic Medicine.  Refers to a form of holistic, alternative medicine developed in India.  The term “ayurveda” derives from two Sanskrit words: ayu, meaning life, and veda, meaning science.  Ayurvedic skincare focuses on plant extracts and essential oils that produce some of the most effective anti aging skin care ingredients.

Natural Anti AgingBentonite.  A clay that dries down to absorb oil from the skin.

Beta Hydroxy Acid.  Also known as Salicylic Acid. Aids exfoliation by weakening the links between cells in the outer layer of dead skin, allowing the normal shedding process to occur at a more optimum rate.  By helping new cells surface, it improves skin texture, unclogs pores, enhances penetration (and therefore effectiveness) of ingredients such as Vitamin C.  It may also play a role in building skin-firming collagen and elastin, especially when incorporated into a two-step chemical peel.  Although synthetic, it is close in structure to an acid that occurs naturally in skin, making it generally nonirritating.  Dr. Gross has found that skincare products with several different kinds of acids (AHAs and BHAs) are the most effective and least irritating, because when many acids are combined, each can be used in a lower (i.e. milder) concentration.  Beta Hydroxy Acid is derived from willow bark and birch.  Medical grade BHA is actually synthesized in a laboratory.

NatureAnti Aging Skin Care Ingredients Grape Seed OilBioflavonoids.  Plant pigments whose potent antioxidant powers keep fruits and vegetables from turning brown. Act as powerful antioxidants in the body and considered effective free-radical scavengers.  Also essential for the stability and absorption of antioxidant, Vitamin C, one of the key collagen-building catalysts.  Found in apricots, cherries, cantaloupe, papaya, grape seed extract, citrus fruits, black tea, onions, parsley, legumes, red wine, red grapes and all blue and purple berries.

Anti Aging ScienceNatural Anti AgingBisabolol.  Found as a natural component of chamomile, Bisabolol is an effective anti-irritant and anti-inflammatory ingredient.  It is very soothing and calming for red, irritated skin.

Blackheads.  A plug of keratin and sebum within a hair follicle that is blackened at the surface.

Blueberry Fruit Extract. See Vaccinium Angustifolia.

Broad Spectrum Protection.  Protects from both ultraviolet light type A and B.  Also commonly noted as UVA and UVB protection.

Natural Anti AgingButyrospermum Parkii (Shea Butter). Skin conditioning agent.

Anti Aging ScienceCaffeine.  An active, natural ingredient found in coffee, tea, cacao and kola nuts that constricts blood vessels in the skin and reduces water leakage.  Alleviates puffiness and under-eye darkness.

Anti Aging ScienceNatural Anti AgingCaprylic/Capric Triglyceride.  Plant-derived emollients that help bind water in the skin to prevent water loss making them  amongst the  top anti aging skin care ingredients.

Natural Anti AgingAnti Aging Skin Care Ingredients Green Tea ExtractCamellia Sinensis (Green Tea Extract & White Tea Extract). A natural antioxidant in the tannin family, rich in chemicals known as polyphenols, which have potent antioxidant properties.  A potent antioxidant shown to neutralize free radicals generated from inflammation, but may also have benefit against DNA mutations that are associated with cancers (of the skin).  May also reverse sun damage.

Natural Anti AgingCentella Asiatica/Gotu Kola.  Derived from the Gotu Kola plant, Centella Asiatica promotes collagen production and is known for its potent wound-healing properties.  It is also a known anti-bacterial agent.

Anti Aging ScienceCeramide. A lipid found in the skin that is necessary for normal skin function.

Natural Anti AgingChamomilla Recutita Matricaria (Chamomile Oil/Extract).  An extract from the flowers and finely dissected leaves of Anthemis nobilis.  Reduces inflammation and soothes sensitive skin.

Anti Aging ScienceNatural Anti AgingChelator. Chemical compounds that neutralize metals such as iron, copper, lead and zinc, ­which absorb into the skin after washing with tap water or are excreted from the skin during perspiration. The Hydra-Pure Chelating Complex™, a proprietary blend of detoxifying chelators removes these impurities, reducing environmental effects that lead to aging skin, acne, redness and irritation.

Natural Anti AgingChrysin.  A powerful antioxidant, a flavinoid, also derived from plant compounds. It is a powerful anti-inflammatory and reduces swelling and puffiness.

Anti Aging ScienceNatural Anti AgingCitric Acid.  A naturally-occurring Alpha Hydroxy Acid derived from the fermented sugars of citrus fruits.  Helps speed up cell turnover/cell renewal.

Cocoa Seed Butter. See Theorbroma Cacao.

Coenzyme Q-10.  See Ubiquinone.

Collagen.  The protein in skin that gives it firmness, structure, keeps it taut and resilient.  With age, collagen is not only produced more slowly and degenerates more quickly, but also diminishes because of sun damage, pollution, free radical damage and genetics.  Depletion of collagen is the main cause of wrinkles.  Fortunately, ingredients that build collagen by either promoting its production or preventing its breakdown can be both consumed in foods and applied topically via anti aging skin care natural products.

Anti Aging ScienceNatural Anti AgingColloidal Sulfur. Reduces oil-gland activity and dissolves the skin’s surface layer of dry, dead cells. This ingredient is commonly used in acne soaps and lotions, and is a major component in many acne preparations. It can cause allergic reactions in some sensitive people.

Comfrey Extract. See Symphytum Officinale.

Anti Aging ScienceCopper PCA.  Powerful humectant that brings moisture from the atmosphere into skin.

Cucumber Extract. See Cucumis Sativus.

Natural Anti AgingCucumis Sativus (Cucumber Extract). It is a natural anti-inflammatory. Works as a mild astringent, yet is gently cooling and soothing and can help reduce puffiness of the skin.

Anti Aging ScienceDiacetyl Boldine (Lumiskin™). Naturally derived from the bark of a Chilean tree, it is a potent antioxidant that brightens and evens skin tone.

Anti Aging ScienceDimethicone.  An oil-free, moisturizing ingredient that helps protect and condition skin and self-adjusts to absorb only where needed.

Anti Aging ScienceDimethyl Sulfone (MSM). Essential to the structure of collagen; an ingredient which supplies sulfur to the skin. Since sulfur has been found to be present in the amino acids that comprise collagen it is believed that incorporating sulfur into skincare products and into a healthy diet could have a huge impact on skin health and preventing – even reversing – the signs of premature aging.

Anti Aging ScienceDipeptide-2. A synthetic peptide containing valine and tryptophan.

Elastin.  One of the skin’s two structural proteins, the other being collagen.  Gives skin its flexibility, enabling it to stretch, then snap back into place.

Emblica. See Phyllanthus Emblica.

Emollient. An ingredient that softens the skin.  Similar in structure to natural lipids found in the skin, helps prevent dryness, soothes irritated skin and makes rough skin smooth.

Enzymes. Enzymes are special proteins that exist in the cells of all living beings. Their purpose is to facilitate naturally occurring biochemical reactions.

Natural Anti AgingEpilobium Angustifolium Extract (Willowherb Extract). A safe, natural anti-inflammatory that works quickly to sooth irritated skin.

Essential Fatty Acids. Sometimes referred to as Vitamin F, essential fatty acids are long-chain polyunsaturated fatty acids derived from linolenic, linoleic  and oleic acids and are crucial to our body’s basic functioning. Since the body cannot make them they must be supplied by food or supplements, which is why they are called “essential” nutrients.  Not only do they regulate several of our bodily functions, including the inflammatory response to injury, they also form part of the structure of cell membranes and are essential for rebuilding cells and producing new ones.  Studies show that EFA’s are essential to the normal health, function, and beauty of the skin.  They can be found in vegetable oils (grape seed, evening primrose, sesame and soybean) and in seeds, nuts, legumes and whole grain products.

Natural Anti AgingEssential Oils. Oils that usually have the characteristic fragrance or flower of the plant.

Natural Anti AgingEvening Primrose Oil. See Oenothera Biennis Oil.

Exfoliant.  An ingredient or device, such as a washcloth or loofah, that revs up cell turnover by sloughing off dead surface cells.  Improves skin texture, evens tone and increases radiance.  Exfoliating acids such as Alpha Hydroxy and Beta Hydroxy Acids may also play a role in building skin-firming collagen and elastin.  In peels, it is not only the exfoliating action of acids that increases collagen formation, but the pH fluctuation the skin experiences as it goes from acidic to neutral.  Dr. Gross has coined the term Phlux to refer to this powerful action, which appears to be an even bigger catalyst in cell renewal.

Anti Aging ScienceFarnesol.   Widely found throughout the plant world and in many essential oils. It inhibits bacterial growth and has antioxidant properties.

Fibroblasts.  Connective-tissue cells that secrete proteins, especially collagen, from which the extracellular matrix of connective tissue forms.

Free Radicals.  Chemicals that destroy collagen and lead to wrinkles, lines, etc.  New research shows that there are at least two different kinds of free radicals – those triggered by the body (metabolic) and those sparked by the sun and other environmental aggressors, such as pollution and smoke.  Both types function like little darts, destroying skin-supporting collagen and elastin, but respond to different antioxidants.  This is why skincare products that incorporate as many different kinds of antioxidants as possible are the most effective.

Natural Anti AgingAnti Aging Skin Care Ingredients Fruit Extract BlueberriesFruit Extracts (Apple, Lemon, Orange).

These make easy do it yourself anti-aging skin care ingredients;
Apple Fruit Extract – an Alpha Hydroxy Acid that exfoliates and tones.
Blueberry Fruit Extract – a powerful antioxidant and anti-inflammatory agent
Lemon Fruit Extract – an astringent that reduces irritation and oiliness.
Orange Fruit Extract – increases circulation and reduces blemishes.
Pomegranate Fruit Extract – a powerful antioxidant

GABA.  See Aminobutyric Acid.

Genistein.  See Soy Isoflavones.

Anti Aging ScienceGlycerin.  A highly effective humectant present in all natural lipids.  Attracts just the right amount of water to skin to maintain balance.  Helps keep skin’s intercellular layer intact, forming a natural barrier that keeps moisture in and skin smooth.

Anti Aging ScienceGlycolic Acid.  A naturally-occurring Alpha Hydroxy Acid derived from sugar.  Helps speed up cell turnover/cell renewal.

Natural Anti AgingGlycyrrhiza Glabra (Licorice Root Extract). Soothes and calms the skin.

Natural Anti AgingGrape Seed Extract.  See Vitis Vinifera.

Natural Anti AgingGreen Tea Extract.  See Camellia Sinensis Extract.

Natural Anti AgingHamamelis Virginiana (Witch Hazel). An extract from the bark of the witch hazel tree with proven astringent, toning, and anti-inflammatory effects.  Also dissolves excess sebum without stripping skin.  Has all the benefits of alcohol without the potential side effects.

Humectant.  A substance used to attract moisture to the skin and retain it.

Hyaluronic Acid.  See Sodium Hyaluronate.

Anti Aging ScienceHydra-Pure Chelating Complex™. A proprietary complex of chelators which remove heavy metals from the surface of the skin, which are impurities that lead to various skin conditions.

Hyperpigmentation. The darkening of an area of the skin caused by an increase in melanin. Hyperpigmentation may be caused by sun damage, acne inflammation, or other skin injuries.

Inhiphase.  See Pueraria Lobata

Jojoba Seed Extract. See Simmondsia Chinensis.

Natural Anti AgingKaolin White Clay Anti Aging Skin Care Natural IngredientsKaolin. A pure, white clay found naturally in the ground. The clay’s mildly drying and disinfectant properties help to heal blemishes, while preventing new ones from forming. It is also great at absorbing moisture and oil on the skin and is one of natures anti aging skin care active ingredients.

Keratosis Pilaris. A very common genetic follicular condition that is manifested by the appearance of rough bumps on the skin and is often referred to as “chicken skin”. It most often appears on the back and outer sides of the upper arms.  It occurs because excess keratin, a natural protein in the skin, accumulates within the hair follicles, forming hard plugs.

Kombuchka. See Saccharomyces/Xylinum/Black Tea Ferment.

Lactic Acid.  A naturally-occurring Alpha Hydroxy Acid derived from dairy products.  Helps speed up cell turnover/cell renewal.

Natural Anti AgingLavandula Angustifolia. Known for healing benefits.

Lavender.  See Lavandula Angustifolia.

Licorice Root Extract. See Glycyrrhiza Glabra.

Natural Anti AgingLinoleic Acid. An unsaturated fatty acid derived from plants, that is essential to skin health.

Lumiskin™. See Diacetylboldine 

Anti Aging ScienceNatural Anti AgingLycopenes.  A newly recognized group of antioxidants derived from red fruits and vegetables, including watermelon, red grapes, red peppers, beets, pink grapefruit and especially tomatoes.  Extremely effective at fending off environmental free radicals, helping to prevent the breakdown of collagen.  May specifically diminish damage from free radicals sparked by the sun.

Anti Aging ScienceMalic Acid.  A naturally-occurring Alpha Hydroxy Acid derived from apples.  Helps speed up cell turnover/cell renewal.

Anti Aging ScienceMannitol.  A sugar based humectant.

Matricaria Oil and Extract. See Chamomilla Recutita.

Medical-Grade Ingredients.  The highest standard used in formulating skincare products, utilizing ingredients synthesized or isolated in the most pure form.

Melasma.  A tan or dark facial skin discoloration. Although it can affect anyone, melasma is particularly common in women, especially pregnant women and those who are taking oral contraceptives or hormone replacement therapy (HRT) medications.  The symptoms of melasma are dark, irregular patches commonly found on the upper cheek, nose, lips, upperlip and forehead.  Melasma is thought to be the stimulation of melanocytes or pigment-producing cells by the female sex hormones estrogen and progesterone to produce more melanin pigments when the skin is exposed to sun.

Microexfoliation™. A gentle, non–irritating method of removing cellular debris from the surface of the skin, resulting in a smoother, firmer more even complexion.

Milia. Benign, keratin-filled cysts that can appear just under the epidermis.

MSM. See Dimethyl Sulfone.

Anti Aging ScienceNatural Anti AgingNiacinamide. One of two principal forms of the B-complex Vitamin B3.  It is a potent antioxidant and is a proven skin-lightening agent.

Noncomedogenic. Not tending to clog pores or cause blackheads.

Anti Aging ScienceOctinoxate.  Chemical sunblock: UVB rays.

Anti Aging ScienceOctisalate.  Chemical sunblock: UVB rays.

Natural Anti AgingOenothera Biennis (Evening Primrose Oil). A botanical property described as an anti-inflammatory, also improves skin hydration. Supplies gamma-linoleic acid, an essential fatty acid.

Natural Anti AgingOlea Europea (Olive Oil).  A natural super emollient; helps active ingredients to penetrate.

Olive Oil.  See Olea Europea.

Organification. The process of organification allows trace minerals beneficial to the skin to be absorbed in a healthy way.

Osmosis Diffusion. Regulates the movement of water into and out of tissues in living organisms through a semi-permeable membrane from a less concentrated solution to a more concentrated one, until both are equalized.

Anti Aging ScienceOxybenzone.  A potent sunscreen that absorbs UVA rays.

Palmitoyl Oligopeptide. The palmitic acid ester of a synthetic peptide consisting of two or more of the following amino acids: alanine, arginine, aspartic acid, glycine, histidine, lysine, proline, serine, or valine.

Palmitoyl Pentapeptide-4. A reaction product of palmitic acid and Pentapeptide-4.

Palmitoyl Tetrapeptide-7. Is the reaction product of palmitic acid and Tetrapeptide-7

SPanthenol.  A Vitamin B complex factor used widely in skin and hair products for its conditioning properties.

Pea Extract. See Pisum Sativum.

Pentapeptide-4. A synthetic peptide containing lysine, serine and threonine.

Anti Aging ScienceNatural Anti AgingPeptide. A  peptide is a polymer consisting of 2 to approximately 20 amino acids connected by peptide bonds, a special linkage in which the nitrogen atom of one amino acid binds to the carboxyl carbon atom of another.

Natural Anti AgingPisum Sativum (Pea Extract). Delivers time-released firming properties.

Phlux.  A term coined by Dr. Gross to refer to the fluctuation in pH that the skin experiences as it goes from acidic to neutral during peels.  Appears to be an even bigger catalyst in cell turnover and collagen formation than conventional exfoliation alone.  It is why it is so important to use both Step 1 and Step 2 of MD Skincare’s Alpha Beta® Daily Face and Body Peels.

Anti Aging ScienceNatural Anti AgingPhospholipids.  Natural substances found in all living cells that help draw water from the air and seal moisture into the skin.

NaturePhyllanthus Emblica. An herb derived from the bark, leaves, flowers and roots of the Phyllanthus emblica tree.  Used in Ayurvedic medicine for many different medical treatments.  Studies show that it has dramatic antioxidant benefits which work synergistically with Vitamin C.

Natural Anti AgingPrunus Amygdalus Dulcis Oil (Sweet Almond Oil). A super emollient and natural oil.

Natural Anti AgingPueraria Lobata Root Extract.  Extracted from the Kudzu Root, it is rich in Isoflavones and Genestein, and has powerful anti-inflammatory properties.  It is very soothing and calming for the skin.

Natural Anti AgingPunica Granatum Extract (Pomegranate). Powerful antioxidants.

Anti Aging ScienceNatural Anti AgingQuercetin Caprylate. Antioxidant that reduces inflammation and soothes skin.

Natural Anti AgingRanunculus Ficaria (Pilewort Extract). Reduces inflammation.

Anti Aging ScienceRetinol.  Vitamin A derived proven anti aging ingredients that reduces skins own collagen-destroying enzymes which accelerate with aging.  Also promotes collagen.  Incorporating both Vitamin C and Retinol into a daily skincare regimen will help combat erosion of both collagen and elastin.  Using a cream or gel with Vitamin C and retinol at night will help to jump-start collagen production.

Natural Anti AgingRicinus Communis (Castor Seed Oil). A plant based skin-conditioning agent.

Rosacea.  An inflammatory acne condition that is often genetic and/or caused by environmental triggers.

Anti Aging ScienceNatural Anti Agingaccharomyces/Xylinum/Black Tea Ferment (Kombuchka). Enhances skin radiance and luster; decreases yellow and grey tones.

Anti Aging ScienceSalicylic Acid.  See Beta Hydroxy Acid.  Enhances penetration (and therefore effectiveness) of ingredients such as Vitamin C.

Natural Anti AgingOrganic Anti Aging Skin Care Ingredients Willow Bark ExtractSalix Alba (Willow Bark Extract). A precursor to both Beta Hydroxy Acids (Salicylic Acid) and aspiring (Acetylsalicylic Acid), it is a potent anti-inflammatory and natural antibacterial agent.

Anti Aging ScienceNatural Anti AgingSodium Ascorbyl Phosphate (SAP). A stabilized form of Vitamin C. It is an essential nutrient for collagen production and also serves as an antioxidant, making them important ingredients in anti aging skin care products

Shea Butter. See Butyrospermum Parkii.

Silybum Marianum Fruit Extract (Silymarin). Potent antioxidant derived from Milk Thistle.

Silymarin. See Silybum Marianum Fruit Extract.

Natural Anti AgingSimmondsia Chinensis (Jojoba Seed Extract). Moisturizes and softens the skin.

Anti Aging ScienceSodium Bicarbonate.  A gentle, naturally-occurring alkaline substance that is a superior neutralizer for acids.

Sodium Hyaluronate (Hyaluronic Acid).  The natural occurring substance in skin that first attracts, then locks water in the dermis, giving skin its thickness and reducing the appearance of wrinkles and lines.  It can hold up to 1000 times its own weight in water.  The “non-oil” component to the skin’s natural moisturizing mechanism.  As we age, our skin’s overall water content, which plumps skin and makes lines less visible, and its hyaluronic acid stores both decline.

Anti Aging ScienceSodium PCA. High-performance humectant recommended for dry, delicate and sensitive skin.

Natural Anti AgingSolanum Lycopersicum (Tomato Fruit Extract – Lycopenes). Helps to reduce wrinkles, fine lines and fend off free radicals; prevents collagen breakdown.

Anti Aging ScienceNatural Anti AgingAnti Aging Skin Care Ingredients Genistein Antioxidant MoleculeSoy Isoflavones (Genistein). An active ingredient found in Soy Extract that stimulates collagen production and diminishes collagen breakdown.  In addition to free radicals, skin contains naturally occurring enzymes that erode collagen.  Genistein, isolated by Dr. Genistein in Switzerland, has been shown to block and diminish these collagen-destroying enzymes significantly.  Also thickens skin dramatically by working like estrogen, but without the negative side effects of HRT (hormone replacement therapy). Gentle for all skin types and non-irritating; works well with all other anti aging skin care ingredients.

Anti Aging ScienceNatural Anti AgingSqualane.  An ingredient that can be found in olive oil, wheat germ oil and rice bran oil. It is an emollient that prevents water evaporation from the skin and it is a constituent of skin.

Sulfur. See Colloidal Sulfur.

Sweet Almond Oil.  See Prunus Amygdalus Dulcis Oil.

Symphytum Officinale (Comfrey Extract). An ingredient that has traditionally been used to treat wounds. The roots and leaves of comfrey contain allantoin, a substance that promotes wound healing and tissue regeneration.

Tego Cosmo. See 1-Methylhydantoin-2-imide.

Tetrapeptide-7.  A synthetic peptide containing arginine, glutamine, glycine and proline.

Anti Aging ScienceTitanium Dioxide.  A physical sunscreen that protects against both UVA and UVB rays.

Natural Anti AgingTheobroma Cacao (Cocoa Seed Butter). Softens and lubricates the skin.

Tomato Fruit Extract. See Solanum Lycopersicum.

Anti Aging ScienceQ10 & Ubiquinol Ingredients For Anti Aging Skin CareUbiquinone (Coenzyme Q-10). A compound that is made in our bodies and used by cells to produce the energy they need to grow and stay healthy.  An antioxidant with actions very similar to those of Vitamin E, it has been found to be an excellent defender against free radicals and, when used regularly over time, may help ease lines and wrinkles by building collagen.

Natural Anti AgingVaccinium Angustifolia (Blueberry Fruit Extract). A powerful antioxidant and anti-inflammatory agent.

Anti Aging ScienceNatural Anti AgingVitamin A.  (Retinyl Palmitate, Retinol and Retinoic Acid).  An antioxidant essential to the maintenance and repair of epithelial tissue.  Stimulates new skin cells and inhibits the body’s natural enzymes that break down collagen. May prevent premature wrinkling.

Anti Aging ScienceNatural Anti AgingVitamin C.  (Ascorbyl Palmitate, Ascorbic Acid, Ascorbyl Glucoside).  An antioxidant vitamin necessary for tissue growth and repair, as well as collagen formation.  One of the best free radical scavengers, it seems to combat free radicals triggered by both the body and the environment.  Works synergistically with Vitamin E.

Anti Aging ScienceNatural Anti AgingVitamin E.  (Tocopheryl Acetate, Tocopherol, A-Tocopherol). The first recognized fat-soluble antioxidant usable in skin.   One of the most potent antioxidants, particularly good at defending against and disabling free radicals made by the body.  Essential to tissue repair.  Works synergistically with Vitamin C.

Natural Anti AgingVitis Vinifera (Grape Seed Extract). A rich source of bioflavonoids, powerful free-radical scavengers and of oligomeric proanthocyanidins, a very potent antioxidant.

Water-Soluble Silicones. Oil-free, noncomedogenic, active ingredients in anti-aging skin care that replenish moisture, prevent further moisture loss and self-adjust to skin’s needs, absorbing only where needed.

Natural Anti AgingWhite Tea Extract. See Camellia Sinensis.

White Clay. A natural mineral that absorbs excess skin oil.

Willowherb Extract. See Epilobium Angustifolium.

Witch Hazel.  See Hamamelis Virginiana. 

Anti Aging ScienceZinc Oxide. Broad spectrum UVA/UVB protection, physical sunscreen.

Anti Aging ScienceZinc PCA. Links the amino acids necessary for collagen formation; prevents damage to collagen and elastin fibers.

I hope that helps you understand better these ingredients for anti aging skin care and whether they are anti aging skin care natural ingredients or not.

Thanks must go out to Dr. Dennis Gross for compiling this useful glossary of anti aging skin care ingredients.

 Dr Dennis Gross On Anti Aging Skin Care Ingredients

Dr. Dennis Gross talks about the benefits of using anti aging skin care ingredients like Vitamin D.

Anti Aging Skin Care Ingredients | Glossary Of Terms by Dawn Flange is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike CC BY-NC-SA 4.0.
Based on a work at


Anti Ageing Supplements

Anti Ageing Supplements

Anti Ageing Supplements ScienceAs in many other walks of life science is also leading the way in the search for new and effective anti ageing supplements.

Seems that those heading towards their golden years are not as willing to simply accept what in the past had been thought of as inevitable and are in fact the very first generation of youthful senior citizens.

They desire to look and feel young, not willing to accept ageing skin, grey hair, lines or wrinkles. They are spending more time in the gym and more money on anti aging products in their quest for a longer more active retirement. This has resulted in science taking the lead in the pursuit of essential anti aging supplements designed to add to the longevity of this new breed of “pensioner”.

One recent discovery by an Australian has led to the development of a drug that has the potential to slow down the aging process. SIRT1, an enzyme found naturally in the body, has been identified by scientists as one means of fending off age related disease and so expanding the bodies life-span.

The diseases it may have success with are those we are hearing more and more about every day. Cancer, diabetes and Alzheimer are all very much in the news but with the help of these life extension anti aging supplements they could become some thing we would no longer need to fear as we get older.

Anti Aging Supplements DNA ResearchAs DNA (deoxyribonucleic acid) strands are unraveled, and we understand more about how we tick, an increased number of  studies are taking place in areas away from extending life expectancy. As I mentioned above, baby boomers are looking for the best anti-aging supplements to take to fight off or even reverse such things as facial lines and wrinkles, aging skin, greying hair and bulging waistline. For example, a Boston dermatologist is reported to be working on a solution to aging skin that involves protein enzymes supplements.

Recent advances in scientifically proven anti aging supplements, targeted towards anti-aging dietary supplements needs, means there are numerous products readily available, which are easily implemented and able to help fight off and even reverse visual signs of aging skin.

In our FREE anti aging supplements pdf, Anti Aging Made Easy, you will find many ways to fight back against the aging process. These are perennial methods that can help you pinpoint where you can improve your anti aging strategy, along with tips to take on the aging process and ultimately turn back the clock.

Don’t just age gracefully without a fight, you don’t have to. You can look for anti ageing supplements already developed and uncover the latest findings like stem cell anti aging supplements that will help you turbo-boost your wellness and see measurable results for the efforts you put in to stay young, look young, and feel young, not just today but in the months and years ahead.

Clinically Proven Anti Aging Supplements

David Wolf Interview with Lisa Garr looking into clinically proven anti aging supplements.

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Anti Aging Cream For Men : Protect Aging Skin

Anti Aging Cream For Men

Anti Aging Skin Care Cream For MenFor men, the quest to remain looking young has over the last decade steadily become a passion, even more so now that the baby boomers relentlessly move through their fifties and on towards retirement. You only have to turn on the T.V. to see it in the anti aging cream for men adverts that are running. Companies can now realistically state that aging skin can be defeated, meaning skin will stay smoother, softer and wrinkle free for many more years. In the past it has been too easy to dismiss this as simple vanity, but there is a a valid argument that by taking good care of your aging skin your whole body will reap the rewards of your hard work during your twilight years.

Being men you don’t always think too long about your skin when you are young, after all in your twenties or thirties it just looks after itself doesn’t it? Those cuts and abrasions you get always heal in just a short time don’t they? If only men had taken a little bit more interest during those years they would have realized that the skin is in fact a vital organ, as important to their overall health as the heart, liver, kidneys.

It’s true to say that for the majority of 50 something men, maintaining their health has taken on a much bigger importance for them than it ever was for their fathers. We are better educated in the dangers modern life holds for the heart, the risks of cancer are also well documented, as are the dangers to our health diabetes presents. This awareness has only come about because of the different health initiatives governments in all developed countries have implemented in recent times. It is strange then, given that the skin is the bodies largest organ, that it is the baby boomers who have taken hold of the fact that putting in place an anti aging regime for their skin will hold them in good stead during their old age.

Anti Aging Cream For Men & Cell Hydration

Simple thing like skin cell hydration, either through drinking more water or by using the best anti aging face cream or moisturizers will stave of the lines and wrinkles, a result of skin dryness, that leave the body more susceptible to serious health issues.

Other simple lifestyle changes as men get older will keep them on course for a long and healthy retirement. That said, the earlier these are put in place the better men’s anti aging skin care system it becomes.

  • Protecting skin from extremes of temperature such as harsh wind, cold and high temperatures will reduce the chances of premature aging.
  • Be aware of the effects of the sun on skin aging and get to know the reasons why you should be using anti aging cream for men that have a sun protection factor of at least 30. Forget the tan, in the short term you might look the bomb, but as you get older your skin can become heavily wrinkled and very unpleasant to look at.
  • Not something baby boomers Dads would have ever considered, but keep clear of soap and don’t scrub away at your skin to hard. Clean skin is an essential part of an effective anti aging regime but harsh soaps only strip the skin of it’s naturally produced lubricants.
  • Anti Aging Men SmokingIf you only do one thing to change your lifestyle make it giving up smoking if you do. I don’t think there is anyone left who doesn’t know the dangers to health that smoking presents, what most don’t know is just how bad it is for aging facial skin, in particular around the lips. You only have to look to see those deep lines and wrinkles that are evident on most smokers faces. If you do smoke give it up A.S.A.P..

Yes, your skin is constantly under attack from many angles. Skin care using top men’s anti aging products can go a long way towards slowing down the signs aging have on men’s skin, but don’t obsess about it. It can do more harm than good if you overdo it. When using anti aging cream for men do stick to the directions, don’t get despondent and try applying double what is recommended if you don’t see immediate results. Your skin care regime is a long term strategy to keep aging skin at bay whatever age you start at.

Take on board those small lifestyle changes above, those are going to care for your skin so it cares for you by keeping you healthier for longer. As well as anti aging cream try applying coconut oil on your face at night to keep the skin smooth and plump up the cells so fine lines and wrinkles look less prominent. Eat plenty of fresh fruit and veg and drink plenty of clean water. A good Mediterranean anti aging diet should give you all the vitamins and minerals you need, if not there are an abundance of high quality anti aging supplements for men that will also be beneficial to take.

If we are fortunate enough, we are all eventually going to get old, men are no different it just takes them a little longer to realize that’s all, but by using the top men’s anti aging cream for men means you will not have to look old.


Top Men’s Anti Aging Cream Video


5 Of The Best Anti Aging Treatments Products

Best Anti Aging Treatments

Anti Aging Issue Good Housekeeping MagazineSome time ago, in a past issue of the publication Good Housekeeping, they highlight the results of a massive volunteer study they did to shortlist and choose 5 of the best anti aging treatments. They based their results on actual scientific results.

Here are the anti aging products reviews of the 5 top rated anti aging products, plus the runner up in each category. The categories are as follows; body lotion, eye cream, instant wrinkle smoother, lip treatments and facial moisturizers with a SPF of at least 30.

All of these top rated anti aging products can help in your bid to slow the aging process, and in certain situations even drastically reverse any damage that might have been done in the past on your face and body.

Best Anti Aging Treatments Body Lotion

As we get older, our skin cells are easily shed which can leave us looking dry and wrinkled. To keep our skin beautiful and looking youthful, the need for us to better hydrate our skin, moisturize and exfoliate regularly grows.

Fresh Sugar Acai Anti Aging Body CreamThe winner in the category best anti aging body lotion was won by Fresh Sugar Acai Age-Delay Body Cream.

The luxurious moisturizer lists in it’s ingredients the antioxidants your body needs to help it fight off cancers. A 6.8 ounce bottle has in it many vitamins designed to repair sun damage as well as damage from other airborne free radical toxins your skin encounters in every day life

The fatty acids found in this anti aging body lotion help remove toxins from your skin’s cells allowing for more cell hydration. This process is going to hydrate and plump your aging skin to reduce visible sagging and wrinkles

Fresh Sugar Acai Age Delay Anti Aging Body Cream does not only help firm and tone your skin. Your body is rid of dead skin cells due to the exfoliating aspect of the product, keeping your skin healthy and glowing.

Second in this category is the bigger 7.3 ounce Aveeno Positively Ageless Skin Strengthening Anti Aging Body Cream, which for those on a tight budget could be a far better option

This skin nurturing formula contains Shiitake Mushrooms which contain kojic acid, the effects of which are to rid your skin of age spots and any inflammation present in your skin. Proven to be excellent on dry, crazed skin, you will want to use this if your skin is prone to cracking through extreme dryness to help strengthen and firm.

Anti Aging Eye Cream

Many people claim that skin on the hands are first to age, and they might be right, but we all tend to worry more when those fine lines and dry, sagging skin is facial, no doubt because it’s the first thing we see in the mirror in the morning and also the first thing people look at when we meet. And eyes are the area of the face we obsess about the most.

Amore Pacific Time Response Eye Renewal Anti Aging Creme Image OneIn this category, Amore Pacific Time Response Eye Renewal Anti Aging Creme was voted as the best anti aging treatments for eye skin care due to the wonderful results it delivers around the eye region. Although the product is only half an ounce, it will last a long, long time if used as directed. If the budget is tight ladies this is not for you as it is not a cheap for such a small amount but results are what matters and this delivers.

We know the signs of aging that are common around the eyes; fine lines; dark bags; crows feet; to name but a few, if you notice any appearing this product will not only firm those areas but it will turn the skin around the eyes from that dull, un-shiny look to a more luminous, natural, youthful glow.

In the past, when you were younger and your skin could take the harsh treatment, you probably applied anti aging facial treatments quite vigorously. Now you are older the skin around the eyes is more susceptible to damage from such treatment so care should be taken when using anti aging eye products. Gently pat the product onto the skin, don’t rush it, take your time and use your little finger, you don’t want to further damage the skin in this area.

Second was Perricone MD Hypoallergenic Firming Anti Aging Eye Cream. This hypoallergenic product comes in at just half an ounce as well and also promises to firm up the skin around the eye area. The main active ingredient are tocotrienols, which are a crucial component of the vitamin E.

For protecting the skin from things like sun damage and smoke, Perricone MD employs olive polyphenols. Marketed as food for the skin, applied topically the potent antioxidants it contains are able to reduce and depress inflammation and improve skin disorders.

Anti Wrinkle Skin Care

I don’t personally know of one single woman who is comfortable with their wrinkles. Obviously we instantly notice the ones that pop up on our face but they have also have this (bad) habit of appearing in other place on the body.

Anti Aging Product From Skyn Iceland Angelica Line SmootherTo rid yourself of these little blighters, the winner of the anti wrinkle skin care category, Skyn Iceland Angelica Line Smoother, uses a unique blend of portulaca extract, ginseng, tomato extract and rice bran, all packed into a 1.5 fl. oz. container.

Not one I have used myself in the past, but it recommends using as a spot treatment and working into the lines and wrinkles around the mouth and eyes. It is said to start working in only ten minutes by relaxing facial muscle tension, the cause of the appearance of lines and wrinkles. Due to the small amount used, because you are not smothering the area to be treated, this will last you a long time.

It claims to help by increasing collagen production and enriches your skin with the minerals from the Icelandic water it contains. Berries and extracts are also included which help de-stress the skin around the eyes and mouth

Fatty acids that plump the skin and offer cells protection from toxins and many other every day hazards that your skin is subjected to. Aimed at those who are uneasy with botox but who want the results botox can give.

Voted as runner up, Dr. Lewinn Instant Dermal Wrinkle Filler by Kinerase comes in a miniscule 0.4 ounce container but has the massive benefit of being kind to all types of skin even if you are sensitive to other anti aging wrinkle products.

This product also claims just a ten minute waiting time before you are able to see some results. It’s ingredients are designed to work at keeping your skin looking younger by restoring health to the skins cells.

Although aging skin is a major cause of fine lines and wrinkles there are many other factors that can accelerate their appearance, you need to be aware of these and always look at taking precautionary measures no matter what anti wrinkle skin care lotion you use. Two of the biggest causes are through smoking, which causes lines around the top lip and corners of the mouth, and exposure to the sun. Both are preventable, it’s always worth thinking before hand of the long term damage these activities can do to your skins age health.

Anti Aging Lip Treatment

Kissable_Lips_Anti Aging Lip TreatmentMan or woman, who doesn’t like to have beautiful looking, plump, smooth and kissable lips, and also see the same on their other half? Why would we ever want to put up with lips that are dry, wrinkled or even cracked. To maintain your ageing lips you need the best anti aging lip treatment on the market and nothing less.

Fresh Sugar Advanced Therapy Anti Aging Lip TreatmentThe winner of the anti aging lip treatment category does everything you need a lip treatment to do…give you youthful looking lips. The Fresh Sugar Advanced Therapy Anti Aging Lip Treatment product comes packed in a container that weighs in at just 34 milliliters. Again that doesn’t sound a lot but you are only going to require a small amount, and it is for the lips, so this is going to last a long time.

When you reach for the chap stick, when your lips are cracked or look and feel as though they have been damaged through the cold, wind or sun, think on how often you do this, probably to the point where your lips are sore from applying it so often. With Sugar Advanced Therapy Anti Aging Lip Treatment your first impressions will be just how much longer the product lasts.

To restore health to your lips it feeds them with the nutrients they require, then the beauty fortifying ingredients the product contains go to work to assist with the antiaging process. The passionflower seed oil, plum seed oil, and cupuacu butter hydrates your lips so they will appear much fuller and the sea fennel will work on the wrinkles making the skin feel supple and smooth again.

We are all aware of the punishment our skin takes from free radicals present in the environment, well this is taken care of on the lips by the inclusion of orange extract in this product. It normally takes a few hours to see any results but customers are seeing great improvement on and around the lip area in as little as only six hours but expect to see amazing results in about four weeks of regularly using the product.

The company used a group of invited testers to try out this product as part of their every day anti aging skin care regimen and they all had fantastic results. Every one of those invited to use the product reported that there lips looked and felt better after using this Anti Aging Lip Treatment. They found that by applying this under their lipstick less damage was done to their lips during the day. Apply the product through the day and when you go to bed to attain optimum results.

The next best anti aging lip treatment was voted as VENeffect Anti-Aging Lip Treatment. It is designed to hydrate the vertical fine lines on both the lips and surrounding skin, it comes in a tiny 10ml container and is manufactured in the USA.

Used twice a day, preferably under your normal lip-stick, this hypoallergenic anti aging lip treatment is perfect for those with sensitive skin and is also said to help return the rosiness to the lips that we lose as we get older.

Anti Ageing Facial Moisturizer (With SPF 30)

Nothing has such a negative impact on your anti aging facial skin care than the sun…fact. Whether from the increase in the risk of skin cancer or from the damage done to your skin from the harsh rays, the sun is public enemy number one when it comes to facial anti aging. But help is at hand in the form of Neutrogena Rapid Wrinkle Repair with SPF30, voted number one anti aging facial cream.

Best Anti Aging Moisturizer Neutrogena Rapid Wrinkle Repair With SPF30Using only an amount the size of a pea, which is good because you get a full one ounce of product, you can safely apply the product to the whole face and neck area and the Retinol Sa present in the product immediately works on the lines and wrinkles, plumping and smoothing them away. You also get the benefit of full UVA and UVB protection making it perfect for everyday use.

Best applied in the morning, before you put on your make up. Massage the product in, applying to the face and neck, then allow it to absorb and dry completely before applying your foundation etc.

Multi Correxion Lift Anti Gravity Day Anti Aging MoisturizerNext best anti aging facial products was Roc Multi Correxion Lift Anti-Gravity that comes in a 30% larger container at 1.3 ounce. You apply it much the same as any anti aging facial cream daytime moisturizer. This is another great anti aging product to help prevent sun damage to the face as it includes retinol and has a SPF of 30.

Consumer reviews highlight how the product has the ability to even out over time the tone of the skin, which in layman’s terms means that age blotchiness is reduced or even eradicated completely. Most all users commented on the youthful look they were able to achieve after only a small amount of use.

Customers even reported a lack of the need to wear foundation under their make up after applying the product, as the results they got were far superior with just the Roc Multi Correxion Lift Anti-Gravity.

It may seem early, but, like a pension, it is best to begin your anti aging regimen as early as in your teens, though few seldom do. Even if you are advancing in years or consider you may have passed the point where any anti aging skin care would be a waste of time, it’s never too late to begin just one of the many available anti aging systems. Get out there and give it a real go, it can and will make a difference to your appearance.

All good anti aging products in their own right, these are going to help you fight the signs of aging, but never forget even though it’s important to treat your skin topically, hands; face; body; it is just as important to consume the correct anti aging foods. Proper nutrition is essential for supplying the nutrients and vitamins you need to look good on the outside and also protect what you can’t see on the inside.

Cleanse, Tone & Moisturize

This video shows how you should implement cleansing,  toning and moisturizing as part of a program of anti aging beauty treatments. One of the videos from Liz Earle Naturally Active YouTube channel.



Natural Anti Aging Skin Care : What It Is What It Isn’t

Natural Anti Aging Skin Care

Natural Anti Aging Skin CareNatural anti aging skin care, put simply, is a method of skin care using products that contain natural anti-aging skin care ingredients with no chemicals added. By going the “all natural anti aging skin care” route you will enable your aging skin to heal itself without adding to the problem by applying synthetic materials or chemicals to your already sensitive skin.

By getting into a healthy, daily routine, much the same as you would if you were changing to a healthy eating diet, you will be able to see the difference in the appearance of your skin. Wrinkles will reduce in severity, fine lines will disappear and people will comment on how healthy your skin looks, after a shorter than anticipated length of time.

Some Of The Best Anti Aging Skin Care Measures

I know this sounds all too easy, but first step is to simply get into the habit of drinking about eight glasses of water a day. By doing this you will give your skin a massive boost. This one step will give you the visible improvements to your skin you are looking for and in super quick time too. Drinking this amount of water will flush out harmful toxins from your body naturally, so not only outwardly improving your health but improvements to your internal organs as well. It doesn’t have to be bottled water, good old tap water is plenty good enough if you live in a country where the water from the mains is drinkable.

To improve the results try this effective natural anti aging skin care method. Make your first drink in the morning a glass of water infused with the juice from half a squeezed lemon. To this add grated fresh ginger, using a piece about 20mm long and the thickness of your little finger, this will “sweeten” it naturally. This is a powerful concoction. The water will go to help hydrate the brain, which is good for cognitive health, the lemon will help deep cleanse the body and the ginger will give you strength. You can take the chill off it with a little hot water if you like, that’s the way I prefer it. Give it a go, you or your skin won’t regret it.

Natural Anti Aging Skin Care ShowerAnother easy to follow and inexpensive method of natural skin care for anti aging is general cleanliness. Shower (or take a bath) regularly. Clean skin is without doubt healthier than skin that is not clean. Not only will it keep skin disorders at bay but it’s also the perfect time to apply a good natural anti aging body moisturizer to replenish the aging skin you can’t see. Also don’t use harsh soap on your skin. Soap can dry out the sensitive facial skin especially around the eyes and mouth, use a natural anti aging face wash instead.

Another big natural anti aging skin care at home method is to take regular exercise. I know it’s tempting just to sit and watch the TV or do some surfing on the net but it’s important to exercise. Exercising increases the flow of blood to cells and removes toxins from the body. It is also very effective at beating stress, anxiety and depression, all illnesses that will have a massive impact on how your skin will look.

It goes without saying how important it is to consume healthy food. Get into healthy eating habits with a mixed, varied diet. Include plenty of fresh fruit and veg to help remove even more toxins from the body. Eat about 20-25% of your food intake raw, which will not only supply the body with ample nutrients, vitamins and minerals, but recent studies point to water consumed through eating being much more efficient for aging skin hydration.

Getting a good nights sleep is up there with the best natural anti aging skin care tips I can give you. I think we all know by now that the body takes the opportunity to mend itself during the time we are asleep. This healing also applies to the skin and it’s cells. The longer you can sleep uninterrupted the better it is for the skins healing process. Sleep can also help to delay the onset of slacking aging skin.

Stress can also have adverse effects on the health of your skin. Beating or taking control of stress will only have positive effects on the body overall. We know some of the natural anti aging skin care remedies we have already mentioned go a long way to beating or relieving stress but it won’t hurt to add to those methods. Yoga is becoming increasingly popular for it’s stress busting properties, taking a long soak in the bath; a shower just doesn’t cut it as a stress buster, it’s too quick to have any real benefit, listening to your favorite music of taking part in sport or a hobby are all good ways to combat stress.

I regularly answer emails from women, and men for that matter, asking “what is the best natural anti aging skin care“, like there is one magic silver bullet method, and I always un-falteringly answer “keeping out of the sun”. I then go on to explain that I don’t mean not to go outside, after all sunlight is another great feel good ingredient for stress busting, but I mean cover up when you are in it. It’s easier than ever now, to protect our skin with sunscreen. Those (relatively) new anti aging moisturizers with spf 30 mean we should never leave home without first applying some to exposed skin. Carry an umbrella or wear long sleeves, the sun can quickly destroy all the good antiaging work you have done recently.

Applying Anti Aging Sunscreen

Natural Anti Aging Skin Care Sunscreen Directions
So ladies there it is, natural anti aging skin care doesn’t have to be difficult or expensive. A little common sense will go a long way to helping you put in place your own antiaging systems, ones you can live with that will yield visible results for your aging skin.


Check Out This Natural Anti Aging Skin Care Video




Universal Mechanism for Activating Anti Aging Pathway

New Study Validates Longevity Pathway: Findings Identify Universal Mechanism for Activating Anti Aging Pathway

Thanks to where this article was first published.
It looks like we are a step nearer to unlocking the science behind a new generation of anti aging treatments, medicines and tablets.  Read on to get the full picture…

A new study demonstrates what researchers consider conclusive evidence that the red wine compound resveratrol directly activates a protein that promotes health and longevity in animal models. What’s more, the researchers have uncovered the molecular mechanism for this interaction, and show that a class of more potent (anti aging) drugs currently in clinical trials act in a similar fashion. Pharmaceutical compounds similar to resveratrol may potentially be used as anti aging treament and prevent diseases related to aging in people, the authors contend.

These findings are published in the March 8 issue of Science.

For the last decade, the science of aging has increasingly focused on sirtuins, a group of genes that are believed to protect many organisms, including mammals, against diseases of aging. Mounting evidence has demonstrated that resveratrol, a compound found in the skin of grapes as well as in peanuts and berries, increases the activity of a specific sirtuin,SIRT1, that protects the body from diseases by revving up the mitochondria, a kind of cellular battery that slowly runs down as we age. By recharging the batteries, SIRT1 can have profound effects on health.

nti Aging Resveratrol GraphMice on resveratrol have twice the endurance and are relatively immune from effects of obesity and aging. In experiments with yeast, nematodes, bees, flies and mice, lifespan has been extended.

“In the history of pharmaceuticals, there has never been a drug that binds to a protein to make it run faster in the way that resveratrol activates SIRT1,” said David Sinclair, Harvard Medical School professor of genetics and senior author on the paper. “Almost all anti aging drugs either slow or block them.”

In 2006, Sinclair’s group published a study showing that resveratrol could extend the lifespan of mice, and the company Sirtris Pharmaceuticals, which was started by HMS researchers, was founded to make drugs more potent than resveratrol. (Sinclair is a co-founder of Sirtris, a GlaxoSmithKline company, and remains a scientific advisor. Sirtris currently has a number of sirtuin-activating compounds in clinical trials.)

But while numerous studies, from Sinclair’s lab and elsewhere, underscored a direct causal link between resveratrol and SIRT1, some scientists claimed the studies were flawed.

The contention lay in the way SIRT1 was studied in vitro, using a specific chemical group attached to the targets of SIRT1 that fluoresces more brightly as SIRT1 activity increases. This chemical group, however, is synthetic and does not exist in cells or in nature, and without it the experiments did not work. As a response to this, a paper published in 2010 surmised that resveratrol’s activation of SIRT1 was an experimental artifact, one that existed in the lab, but not in an actual animal. SIRT1 activity in mice was, the paper claimed, at best an indirect result of resveratrol, and perhaps even a sheer coincidence.

As a result, a debate erupted over the particular pathway that resveratrol and similar compounds affected. Does resveratrol directly activate SIRT1 or is the effect indirect? “We had six years of work telling us that this was most definitely not an artifact,” said Sinclair. “Still, we needed to figure out precisely how resveratrol works. The answer was extremely elegant.”

Sinclair and Basil Hubbard, then a doctoral student in the lab, teamed up with a group of researchers from both the National Institutes of Health and Sirtris Pharmaceuticals to address this question.

Anti Aging Tablets MedicineFirst, the team addressed the problem of the fluorescent chemical group. Why was it required for resveratrol to rev up SIRT1 in the test tube? Instead of dismissing the result as an artifact, the researchers surmised that the chemical might be mimicking molecules found naturally in the cell. These turned out to be a specific class of amino acid, the building blocks of proteins. In nature, there are three amino acids that resemble the fluorescent chemical group, one of which is tryptophan, a molecule abundant in turkey and notable for inducing drowsiness. When researchers repeated the experiment, swapping the fluorescing chemical group on the substrate with a tryptophan residue, resveratrol and similar molecules were once again able to activate SIRT1.

“We discovered a signature for activation that is in fact found in the cell and doesn’t require these other synthetic groups,” said Hubbard, first author of the study. “This was a critical result, which allowed us to bridge the gap between our biochemical and physiological findings.

“Next, we needed to identify precisely how resveratrol presses on SIRT1′s accelerator,” said Sinclair. The team tested approximately 2,000 mutants of the SIRT1 gene, eventually identifying one mutant that completely blocked resveratrol’s effect. The particular mutation resulted in the substitution of a single amino acid residue, out of the 747 that make up SIRT1. The researchers also tested hundreds of other molecules from the Sirtris library, many of which are far more powerful than resveratrol, against this mutant SIRT1. All failed to activate it.

The authors propose a model for how resveratrol works: When the molecule binds, a hinge flips, and SIRT1 becomes hyperactive.

Although these experiments occurred in a test tube, once the researchers identified the precise location of the accelerator pedal on SIRT1 — and how to break it — they could test their ideas in a cell. They replaced the normal SIRT1 gene in muscle and skin cells with the accelerator-dead mutant. Now they could test precisely whether resveratrol and the drugs in development work by tweaking SIRT1 (in which case they would not work) or one of the thousands of other proteins in a cell (in which they would work). While resveratrol and the drugs tested revved up mitochondria in normal cells (an effect caused activating by SIRT1), the mutant cells were completely immune.

“This was the killer experiment,” said Sinclair. “There is no rational alternative explanation other than resveratrol directly activates SIRT1 in cells. Now that we know the exact location on SIRT1 where and how resveratrol works, we can engineer even better molecules that more precisely and effectively trigger the effects of resveratrol.”

The researchers plan on continuing academic-industry collaborations with the goal of bringing to fruition anti aging drugs that treat diseases associated with aging.

This research was funded by the Glenn Foundation for Medical Research, the Ellison Medical Foundation, the Juvenile Diabetes Research Foundation, the United Mitochondrial Disease Foundation, NIH and NIAID grants (RO1AG028730, PO1AG027211; RO1 AG019719), an NSERC fellowship, the Portuguese Science and Technology Foundation, the Intramural Research Program, and NIH/NHLBI.

Sinclair is a consultant and inventor on patents licensed to Sirtris, a GSK company.

Is Resveratrol An Anti Aging Miracle



Facial Anti Aging Ruined By Contact Lenses

Study Shows How Contact Lenses Can Affect Your Appearance Over Time | AntiAging

And it’s true for both hard and soft contact lenses, according to this new study involving identical twins

While contact lenses might improve your eyesight without the need for clunky glasses, they might also be having an unintended effect on your appearance. According to a new study published in Aesthetic Surgery Journal, use of contact lenses seemingly leads to eyelid droopiness.

Study finds excessive contact lense wearing can lead to droopy eyelids [Getty]Study finds excessive contact lense wearing can lead to droopy eyelids [Getty]

Researchers reviewed photographs of 96 sets of identical twins who met in Twinsburg, Ohio, on a yearly basis from 2008 to 2010, measuring the level of eyelid droopiness (called “ptosis”) in each.

These 39-year-old female identical twins had differing levels of ptosis. The patients were visually identified from a twins database and had individual ptosis measured in each eye. The twin on the left did not wear contact lenses; the twin on the right did wear contact lenses.

The twin on the left did not wear contact lenses whereas the twin on the right did [Aesthetic Surgery Journal]
 [Aesthetic Surgery Journal]

Nine different environmental factors were considered as a potential cause for ptosis, and they were evaluated through an extensive questionnaire and special standardized photography to determine the degree of eyelid droopiness in each twin.

According to the data collected, wearing either hard or soft contact lenses was associated with ptosis. The average difference in eyelid droopiness between twins was 0.5 millimetres. Among twins who didn’t wear contacts, ptosis was around 1.0 millimetre. In twins who wore soft contacts, that number increased to 1.41 millimetres, rising further to 1.84 millimetres for those who sported hard contacts. (Luckily, with the advent of soft lenses, hard lenses have all but disappeared.)

These 65-year-old female identical twins had differing levels of ptosis related to wearing contact lenses. The subject on the left wore soft contact lenses and had less ptosis than her twin; the subject on the right wore hard contact lenses and had more severe ptosis than her twin.

Left twin - no contacts. Right twin - contacts. [Aesthetic Surgery Journal]
[Aesthetic Surgery Journal]

The researchers also looked for links between ptosis and BMI, smoking, sun exposure, alcohol consumption, work-related stress, and sleep — none of which had a statistically significant impact on eyelid droopiness. The association between contact use and ptosis has been long assumed but never proven, says lead study author Bahman Guyuron, MD, FACS, a facial plastic surgeon based in Cleveland, Ohio.

“Since the identical twins are genetically destined to have similar facial and eyelid features, if there is a difference, it is primarily related to the environmental factors,” Guyuron tells Yahoo Health. “We were able to demonstrate that, of the external factors unrelated to the genes or ageing, use of contacts was the only factor that linked to the droopy eyelids.”

Guyuron says the effect they saw was “related to the weakening of the muscles that lift the upper eyelid, and not related to loose or redundant eyelid skin.” And while the mere-fractions-of-a-millimetre difference might seem small, it’s enough to affect vision and appearance.

“Even a minimal droopiness of the eyelids denotes lack of vigor, tiredness, and getting old — often prematurely on the contact lens users,” says Guyuron. And in a culture constantly seeking the fountain of youth, this may matter to some.

Guyuron says that plastic surgeons regularly perform a couple of key procedures for droopiness. According to data from the American Society for Aesthetic Plastic Surgery, 165,714 eyelid procedures and 31,315 brow lifts were performed on patients in 2014.

“Correction of droopy eyelids is one of the simplest and most rewarding surgeries that plastic surgeons do,” says Guyuron. “It is usually a very short procedure, it often requires very minimal recovery, and it makes the patients look younger and more energetic.”

Of course, eyelid droopiness will occur with each passing year anyway — and you can always switch to glasses if you’re concerned about the effects of contact use.

First Published 08/06/15  Yahoo UK and Ireland Lifestyle


Anti Aging Facial Exercises

Anti Aging Facial Exercises

anti-aging-facial-exercises-youngerNo one, men or women, wants their facial skin looking old and tired or worse still covered in fine lines and wrinkles. That also extends to the skin around the neck area. Well, what if you could do a few simple anti aging facial exercises which take little time to complete, but they do return fantastic results. And what if you could also do these exercises and focus on different areas of the face? Lips, cheeks, forehead and neck to name but a few, letting you put more time to the areas of your face that you think needs more work. Sounds like the perfect facial anti aging method to me.

Free Anti-Aging Facial Exercises

At some point in your life, no matter how diligent you have been with your aging skin treatments, the muscles in the face will simply relax. Depending on just how relaxed the muscles go will depend on how much your facial skin will sag and the skin around the eyes goes baggy. The skin along the jaw bone will slacken causing heavy wrinkles and overall the effects will not make for the skin you envisaged. It’s not all doom and gloom and no way is the above scenario inevitable. With a little regular work, anti aging exercise for face and neck can make a difference.
Starting today, you can maintain a smooth wrinkle free skin or considerably tighten the facial muscle if the aging skin process has already started to show it’s tell tale signs. Our anti-aging face and neck exercises are free and will not take up too much of your time. They can even be done sitting in the chair watching TV or at the desk at work, they take that little time and effort yet the results can be amazing.

With them being so simple, you may be asking yourself “anti aging facial exercises, do they work” or more to the point “will they work for me?” I can’t answer the latter, everyone is different and everyone will put in different levels of effort, but as far as do they work the answer is a resounding yes. Best part is you can follow our free anti aging face exercises YouTube channel to quickly learn the exercise techniques.

Anti Aging Facial Exercises Eyes Lips JowlsAnti aging facial exercises are great at fighting the outward signs of aging, helping you tighten the muscles in the face and achieving a more youthful looking skin. And our best anti aging face exercises are not just for mature people, though that facelift look will be more pronounced the older your skin looks at present, they are also perfect for those younger people wanting to keep their youthful looking features.
Let’s put to bed an old misconception, anti aging facial exercises don’t cause wrinkles, they effectively remove them when done correctly. They allow you that facelift but without the pain, long recuperation and astronomical cost of a surgical procedure. Granted, the results are not going to be as extreme but coupled with your anti aging routine they will help deliver a younger, line and wrinkle free complexion.


Facial exercises DO NOT cause wrinkles if done correctly – they actually help to make women and men look younger for longer, without a surgical facelift, by toning facial muscles. Surgical facelifts can be effective, but this type of cosmetic surgery is expensive, and can be traumatic. Why not try the free facial exercises as an alternative to a surgical facelift. The free facial exercises will not be as radical as the facelift, but will assist in achieving a younger looking face, without wrinkles and lines.
Although the main benefit of undertaking anti aging facial exercises is to the faces supportive muscles, there are added benefits to the skin too. Exercise stimulates blood flow to the cells, this delivers nutrients and removes toxins resulting in a more glowing skin tone. Healthier skin cells equal healthier skin.

Anti aging facial exercises are no different to any other type or form of exercise in as much as they should be done on a regular basis. To begin with, I suggest every day to get the muscles in the face, neck and forehead back to where they should be. This should take no longer than a couple of months but you can continue to do the exercises every day until you attain the desired results. When you have reached where you want to be, then to keep the muscles toned and firm, drop back to every other day.

Anti Aging Facial ExercisesYou’re probably thinking now why this is not promoted more. After all there are endless anti aging products about, all aimed at rejuvenating tired aging skin. Well think about it, anti aging creams, lotions and serums can cost a fortune to purchase, and even though they are very effective, and should be included in everyone’s aging skin regimen, they are not free and there lies the reason why exercise is not pushed as an effective antiaging method. Anti aging facial exercises don’t make money for the big pharma companies, cynical but true.

Small blemishes and spots can appear after you start using our free anti-aging facial exercises, don’t worry if you experience this, it’s quite normal and they will disappear very quickly. Your new aging skin regimen will stimulate your skins production of natural lubricants and oils, which in some circumstances cause these spots to appear. Continued exercise will get the skin’s cells back working as they should and the outward appearance of the skin will again become used to the increased activity.

On our blog you can find anti-aging face and neck exercises that will also target the eyes, jowls, cheeks and lips, a complete range of anti aging face exercises that will return your skin to looking firmer and more youthful. Just remember that you should use these facial exercises along side other main stream anti aging treatments to see the best results on your aging skin.